Combinatorial Targeting of Cellular “Housekeeping” Processes to Treat Cancer.

Targeting the ribosome to treat multiple myeloma

Kylee H Maclachlan, Kezia Gitareja, Jian Kang, Andrew Cuddihy, Yuxi Cao, Nadine Hein, Carleen Cullinane, Ching-Seng Ang, Natalie Brajanovski, Richard B Pearson, Amit Khot, Elaine Sanij, Ross D Hannan, Gretchen Poortinga, Simon J Harrison

2024-03-21

The high rates of protein synthesis and processing render multiple myeloma (MM) cells vulnerable to perturbations in protein homeo..

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

H Zhu, KT Chan, X Huang, C Cerra, S Blake, AS Trigos, D Anderson, DJ Creek, DP De Souza, X Wang, C Fu, M Jana, E Sanij, RB Pearson, J Kang

2022-06-01

Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts..

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

J Kang, N Brajanovski, KT Chan, J Xuan, RB Pearson, E Sanij

2021-12-01

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal pro..